FIG. 6.

Effect of MCC950 on inflammation (TNF-α and NF-κB/p65) at 24 h post-TBI. Representative and quantitative analysis of western blots showed significant increase in TNF-α (A) and NF-κB/p65 (B) expression at 24 h post-TBI compared to shams. MCC950 treatment showed a trend toward a decrease in NF-κB/p65 level. Values are expressed as mean ± SEM (n = 8). *p < 0.05 versus sham. NF-κB, nuclear factor kappa B; SEM, standard error of the mean; TBI, traumatic brain injury; TNF-α, tumor necrosis factor alpha.