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. 2018 Jun 1;35(11):1260–1271. doi: 10.1089/neu.2017.5368

Table 2.

Summary of Genes Altered in nbM pS422 Neurons across CTE Stages

Gene abbreviation Group CTE Stage II CTE Stage III CTE Stage IV p value Pairwise comparison (p value) Function
CLCN4 CH 4.11 ± 0.35a 3.61 ± 0.43 3.54 ± 0.27 0.026 II > IV (0.037) Cell homeostasis
CLCN5 CH 6.99 ± 0.87 6.96 ± 0.94 5.7 ± 0.47 0.025 II > IV (0.045)
III > IV (0.044)
Cell homeostasis
CAV1 CYT 4.21 ± 0.33 4.67 ± 0.82 3.57 ± 0.46 0.018 III > IV (0.017) Endocytosis
ADCY3 GP 1.70 ± 0.07 1.75 ± 0.10 1.54 ± 0.11 0.005 II > IV (0.016)
III > IV (0.006)
Intracellular signaling
LIS1 DV 5.20 ± 0.26 5.62 ± 0.45 4.85 ± 0.38 0.012 III > IV (0.011) Cortical development cytoskeleton
CHRNB2 CHOL 3.67 ± 0.59 2.87 ± 0.41 3.18 ± 0.28 0.030 II > III (0.031) Neurotransmission
COMT MONO 3.01 ± 0.19 2.61 ± 0.24 2.92 ± 0.26 0.033 II > III (0.038) Neurotransmission
DDC MONO 4.66 ± 0.30 3.82 ± 0.37 4.30 ± 0.40 0.007 II > III (0.005) Neurotransmission
MAP2 CYT 1.48 ± 0.11 1.66 ± 0.15 1.73 ± 0.15 0.018 II < IV (0.019) Cytoskeleton
tau
CAPN2 PROT 5.59 ± 0.38 4.50 ± 0.33 5.31 ± 0.35 <0.001 II > III (<0.001)
IV > III (0.004)
Cell metabolism
tau
a

Mean ± SD (arbitrary units)

CH, monovalent and divalent channels; CHOL, cholinergic neurotransmission; CTE, chronic traumatic encephalopathy; CYT, cytoskeletal elements; DV, development-related elements; GP, G-protein subunits; MONO, monoamine neurotransmission, nbM, nucleus basalis of Meynert; PROT, protease-related markers.