Table 2.
Gene abbreviation | Group | CTE Stage II | CTE Stage III | CTE Stage IV | p value | Pairwise comparison (p value) | Function |
---|---|---|---|---|---|---|---|
CLCN4 | CH | 4.11 ± 0.35a | 3.61 ± 0.43 | 3.54 ± 0.27 | 0.026 | II > IV (0.037) | Cell homeostasis |
CLCN5 | CH | 6.99 ± 0.87 | 6.96 ± 0.94 | 5.7 ± 0.47 | 0.025 | II > IV (0.045) III > IV (0.044) |
Cell homeostasis |
CAV1 | CYT | 4.21 ± 0.33 | 4.67 ± 0.82 | 3.57 ± 0.46 | 0.018 | III > IV (0.017) | Endocytosis |
ADCY3 | GP | 1.70 ± 0.07 | 1.75 ± 0.10 | 1.54 ± 0.11 | 0.005 | II > IV (0.016) III > IV (0.006) |
Intracellular signaling |
LIS1 | DV | 5.20 ± 0.26 | 5.62 ± 0.45 | 4.85 ± 0.38 | 0.012 | III > IV (0.011) | Cortical development cytoskeleton |
CHRNB2 | CHOL | 3.67 ± 0.59 | 2.87 ± 0.41 | 3.18 ± 0.28 | 0.030 | II > III (0.031) | Neurotransmission |
COMT | MONO | 3.01 ± 0.19 | 2.61 ± 0.24 | 2.92 ± 0.26 | 0.033 | II > III (0.038) | Neurotransmission |
DDC | MONO | 4.66 ± 0.30 | 3.82 ± 0.37 | 4.30 ± 0.40 | 0.007 | II > III (0.005) | Neurotransmission |
MAP2 | CYT | 1.48 ± 0.11 | 1.66 ± 0.15 | 1.73 ± 0.15 | 0.018 | II < IV (0.019) | Cytoskeleton tau |
CAPN2 | PROT | 5.59 ± 0.38 | 4.50 ± 0.33 | 5.31 ± 0.35 | <0.001 | II > III (<0.001) IV > III (0.004) |
Cell metabolism tau |
Mean ± SD (arbitrary units)
CH, monovalent and divalent channels; CHOL, cholinergic neurotransmission; CTE, chronic traumatic encephalopathy; CYT, cytoskeletal elements; DV, development-related elements; GP, G-protein subunits; MONO, monoamine neurotransmission, nbM, nucleus basalis of Meynert; PROT, protease-related markers.