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. Author manuscript; available in PMC: 2018 Nov 22.
Published in final edited form as: ChemMedChem. 2017 Oct 20;12(22):1857–1865. doi: 10.1002/cmdc.201700503

Table 4.

Structure-activity relationships for pyrimidine core replacements and 4-substituted, 2-anilino-pyrimidine inhibition of TSSK2

Compound Structure TSSK2 IC50, nM[a]
34 graphic file with name nihms966135t30.jpg 690 ± 140
35 graphic file with name nihms966135t31.jpg 58 ± 2
36 graphic file with name nihms966135t32.jpg 3800 ± 100
[a]

Mean ± SEM of at least 3 independent experiments.