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ARS induced p38MAPK activation in HUVECs. ARS activated p38MAPK in time-dependent manner (A) and concentration-dependent manner (B). Specific p38MAPK inhibitors SB202190 and SB203580 inhibited ARS-activated p38MAPK (C). SB202190 and SB203580 protected cells from ARS-induced apoptosis (D) and (E). n = 3. ** denotes P < 0.01.
