Figure 3.

Postinfection topical administration of MAb to PNAG reduces bacterial burdens and conjunctival pathology due to S. pneumoniae (D-39 and ATCC8) and S. aureus (LAC) after 48 hours of infection in A/J mice. A total of 10 μg of control IgG MAb (□) or MAb to PNAG (▵) were administered topically onto conjunctiva 4, 24, and 32 hours postinfection. Mice (n = 7 to 8 per group) were euthanized at 48 hours post infection and pathology scores (upper row) and CFU/conjunctiva (lower row) determined. Symbols represent individual animals, black lines the median, and gray lines the 95% CI, and one-sided P values were determined by nonparametric t-tests.