Table 3.

Thirty- and 90-day mortality risk, expressed as hazard ratios, by suPAR levels, entered as either continuous (log-transformed) or in quartiles, at index admission in patients with AE COPD, any COPD and Respiratory failure due to COPD

Outcome	Analysis	Variable	AECOPD (n = 717)		any COPD (n = 2573)		Respiratory failure (n = 265)
			HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value
30-day mortalityb	Univariate	Continuous	2.2 (1.5–3.2)	< 0.0001	2.5 (2.1–2.9)	< 0.0001	1.5 (1.0–2.1)	0.04
		1.quartile	1		1		1
		2.quartile	1.6 (0.5–4.9)	0.42	2.0 (1.1–3.5)	0.02	1.2 (0.6–2.7)	0.62
		3.quartile	3.3 (1.2–9.0)	0.02	3.3 (1.9–5.6)	< 0.0001	1.1 (0.5–2.4)	0.82
		4.quartile	3.7 (1.4–10.1)	0.01	7.6 (4.6–12-6)	< 0.0001	1.8 (0.9–3.7)	0.12
	Multivariatea	Continuous	1.8 (1.2–2.8)	0.005	2.0 (1.7–2.4)	< 0.0001	1.3 (0.8–2.0)	0.23
		1.quartile	1		1		1
		2.quartile	1.2 (0.4–3.8)	0.73	1.5 (0.8–2.6)	0.20	1.2 (0.5–2.7)	0.66
		3.quartile	2.3 (0.8–6.6)	0.11	1.8 (1.1–3.2)	0.03	0.8 (0.4–1.9)	0.65
		4.quartile	2.0 (0.7–5.7)	0.20	3.4 (2.0–5.9)	< 0.0001	1.3 (0.6–2.8)	0.50
90-day mortalityc	Univariate	Continuous	2.5 (2.0–3.3)	< 0.0001	2.3 (2.1–2.6)	< 0.0001	1.5 (1.1–2.2)	0.01
		1.quartile	1		1		1
		2.quartile	2.1 (0.9–5.3)	0.1	1.9 (1.2–2.9)	0.007	1.1 (0.6–2.4)	0.72
		3.quartile	4.9 (2.2–11-1)	0.0001	3.6 (2.4–5.4)	< 0.0001	1.0 (0.5–2.1)	0.98
		4.quartile	7.1 (3.2–15.8)	< 0.0001	7.3 (4.9–10.8)	< 0.0001	1.6 (0.8–3.1)	0.20
	Multivariatea	Continuous	2.2 (1.6–2.9)	< 0.0001	2.3 (2.1–2.6)	< 0.0001	1.4 (1.0–2.1)	0.06
		1.quartile	1		1		1
		2.quartile	1.8 (0.7–4.5)	0.19	1.5 (0.8–2.6)	0.20	1.1 (0.6–2.4)	0.72
		3.quartile	3.9 (1.7–8.9)	0.001	1.8 (1.1–3.2)	0.03	1.0 (0.5–2.1)	0.98
		4.quartile	4.3 (1.9–9.9)	0.0005	3.4 (2.0–5.9)	< 0.0001	1.6 (0.8–3.1)	0.20

^aAdjusted for age, sex, Charlson score and CRP

^bNumber of events were 45, 227 and 52 in AECOPD, any COPD and Respiratory failure, respectively

^cNumber of events were 93, 358 and 67 in AECOPD, any COPD and Respiratory failure, respectively