Table 3.

Multivariable-adjusted odds ratios of chronic kidney disease by Dichotomized^a Angiogenesis-related Factors

	Age, gender, and race-adjusted			Multivariable-adjustedb
	Odds ratios	95% CI	p-value	Odds ratios	95% CI	p-value
VEGF-A ≥ 160.7 pg/mL	1.84	1.17–2.90	0.01	2.40	1.20–4.81	0.01
Angiopoietin-1 ≥ 5659.5 pg/mL	0.87	0.55–1.36	0.54	1.15	0.57–2.32	0.70
Angiopoietin-1/VEGF-A ≤ 24.2	3.19	2.00–5.10	< 0.001	3.59	1.80–7.18	0.0003
VEGFR-1 ≥ 159.7 ng/mL	1.10	0.70–1.75	0.68	1.36	0.67–2.75	0.40
VEGFR-2 ≥ 28.3 ng/ml	1.28	0.81–2.01	0.29	1.11	0.55–2.22	0.78
Pentraxin-3 ≥ 1.13 ng/mL	1.86	1.18–2.94	0.008	1.74	0.86–3.52	0.13

^aDichotomized as upper tertile compared to lower two tertiles for all biomarkers except the ratio of angiopoietin-1/VEGF-A, which was dichotomized as lowest tertile compared to upper two tertiles

^bAdjusted for age, race, gender, current cigarette smoking, weekly alcohol consumption, physical activity ≥twice/week, BMI, LDL-cholesterol, HDL-cholesterol, C-reactive protein, fasting plasma glucose, systolic BP, use of aspirin or lipid-lowering, antihypertensive, or antidiabetic medications, and history of CVD