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. 2018 May 21;9:143. doi: 10.1186/s13287-018-0883-4

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Schematic of electromagnetic field (EMF)-increased mesenchymal stem cell (MSC) migration by signaling through increased intracellular Ca²⁺ and focal adhesion kinase (FAK)/Rho GTPase pathways. EMF increases intracellular Ca²⁺. The intracellular Ca²⁺ accumulation then activates FAK, leading to the formation of focal contacts and Rho GTPase mediating the organization of the cytoskeleton, which together increases the migration of MSCs