Table 1.

Critical miRNAs as potential diagnostic, therapeutic, prognostic targets in PDAC

miRNAs	Function	Expression in tumor	Targets	Pathway	Ref.
miR-21	Oncogenic	Up-regulated	PTEN, PDCD4, CDK6, CDKN1A, IL-6R, FAS, TPM1, APAF1, SOCS5	PI3K/AKT	[20–22]
miR-34	Tumor suppressor	Down-regulated	NOTCH, BCL2, VEGFA, CCND1, CDK6	p53/p38-MAPK/NOTCH PI3K/AKT	[14, 24, 26]
miR-200 family	Tumor suppressor	Down-regulated	E-cadherin, ZEB, Vimentin	NOTCH, EMT	[14, 20, 23]
Let-7 family	Tumor suppressor	Down-regulated	KRAS, HRAS, LIN28, HMGA2, NF2, TRIM71	EMT, KRAS	[16]
miR-15a	Tumor suppressor	Down-regulated	WANT3A, FGF7, BMI-1	ERK/AKT, EMT	[28, 29]
miR-506	Tumor suppressor	Down-regulated	SPHK1, PI3M	SPHK1/AKT/NF-κB	[31, 32]
miR-221	Oncogenic	Up-regulated	KIT, CDKN1C, CDKN1B	EMT, PKC/NF-κB, PTEN/PI3K/AKT	[14, 21]
miR-96	Tumor suppressor	Down-regulated	KRAS, AKT	KRAS, PI3K/AKT	[14, 15]
miR-17-92	Tumor suppressor	Down-regulated	p21, p57, TBX3	NODAL/ACTIVIN/TGF-1	[18]
miR-145	Tumor suppressor	Down-regulated	KRAS, RREB1	KRAS, PI3K/AKT	[14]
miR-155	Oncogenic	Up-Regulated	TP53INP	Apoptosis, Exosome Synthesis	[30]