Table 2.
Univariate and multivariate analyses of variables for overall survival in AML patients
| Variables | Complete remission | Overall survival | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
| OR (95% CI) | P | OR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| miR-200a | 0.548 (0.242–1.244) | 0.150 | 1.029 (0.285–3.722) | 0.965 | 0.662 (0.415–1.022) | 0.082 | 1.425 (0.651–3.120) | 0.376 |
| miR-200b | 0.384 (0.167–0.885) | 0.025 | 0.823 (0.199–3.401) | 0.788 | 0.511 (0.319–0.819) | 0.005 | 0.524 (0.305–0.902) | 0.020 |
| miR-429 | 0.384 (0.167–0.885) | 0.025 | 0.331 (0.128–0.858) | 0.023 | 0.558 (0.350–0.891) | 0.015 | 0.820 (0.325–2.073) | 0.675 |
| miR-200c | 0.384 (0.167–0.885) | 0.025 | 0.977 (0.149–6.400) | 0.981 | 0.606 (0.380–0.965) | 0.035 | 0.649 (0.190–2.217) | 0.491 |
| miR-141 | 0.460 (0.201–1.050) | 0.065 | 0.594 (0.192–1.833) | 0.364 | 0.695 (0.437–1.104) | 0.123 | 1.152 (0.582–2.279) | 0.684 |
| Age | 4.229 (1.742–10.266) | 0.001 | 4.555 (1.715–12.095) | 0.002 | 2.046 (1.282–3.266) | 0.003 | 1.732 (1.033–2.902) | 0.037 |
| WBC | 2.367 (1.015–5.520) | 0.046 | 1.846 (0.715–4.767) | 0.206 | 2.002 (1.253–3.199) | 0.004 | 1.560 (0.925–2.629) | 0.095 |
| Karyotype | 3.108 (1.338–7.220) | 0.008 | 2.862 (1.164–7.042) | 0.022 | 1.875 (1.295–2.715) | 0.001 | 1.874 (1.210–2.902) | 0.005 |
| CEBPA mutations | 0.526 (0.160–1.731) | 0.290 | 0.870 (0.413–1.829) | 0.713 | ||||
| NPM1 mutations | 0.833 (0.207–3.358) | 0.798 | 1.200 (0.516–2.793) | 0.672 | ||||
| FLT3-ITD mutations | 0.833 (0.207–3.358) | 0.798 | 0.935 (0.403–2.170) | 0.876 | ||||
| C-KIT mutations | 0.673 (0.041–11.150) | 0.783 | 0.479 (0.066–3.458) | 0.465 | ||||
| N/K-RAS mutations | 3.048 (0.605–15.343) | 0.177 | 1.311 (0.621–2.770) | 0.478 | ||||
| IDH1/2 mutations | Undetermined | 0.999 | 4.671 (1.637–13.326) | 0.004 | 6.662 (1.757–25.268) | 0.005 | ||
| DNMT3A mutations | 1.391 (0.240–8.057) | 0.712 | 1.590 (0.634–3.987) | 0.323 | ||||
| U2AF1 mutations | Undetermined | 0.999 | 2.791 (0.987–7.890) | 0.053 | 5.130 (1.714–15.355) | 0.003 | ||
| SRSF2 mutations | Undetermined | 0.999 | 1.934 (0.693–5.400) | 0.208 | ||||
| SETBP1 mutations | 0.673 (0.041–11.150) | 0.783 | 0.637 (0.088–4.613) | 0.656 | ||||
OR odd ratio, HR hazard ratio, CI confidence interval. Variables including miR-200s cluster expression (Low vs. High), age (≤ 60 vs. > 60 years), WBC (≥ 30 × 109 vs. < 30 × 109/L), karyotype (favorable vs. intermediate vs. poor), and gene mutations (mutant vs. wild-type). Multivariate analysis includes variables with P < 0.200 in univariate analysis