Table 3.
Top ten significant GO terms enriched by targets of the identified microRNA biomarkers
| Category | GO terms | Number of enriched genes | Adj.p value |
|---|---|---|---|
| BP | Mitotic cell cycle | 60 | 3.52E−07 |
| Phosphorus metabolic process | 112 | 4.00E−06 | |
| Phosphate metabolic process | 112 | 4.00E−06 | |
| Regulation of apoptosis | 97 | 3.51E−06 | |
| Positive regulation of cell proliferation | 61 | 2.83E−06 | |
| Cell cycle process | 75 | 3.16E−06 | |
| Regulation of programmed cell death | 97 | 2.92E−06 | |
| Regulation of cell death | 97 | 3.02E−06 | |
| Cell cycle | 93 | 4.11E−06 | |
| Regulation of transcription from RNA polymerase II promoter | 88 | 6.10E−06 | |
| CC | Nuclear lumen | 162 | 1.17E−13 |
| Nucleoplasm | 110 | 7.25E−12 | |
| Organelle lumen | 182 | 1.05E−11 | |
| Membrane-enclosed lumen | 183 | 2.45E−11 | |
| Intracellular organelle lumen | 176 | 5.37E−11 | |
| Nucleoplasm part | 77 | 1.95E−10 | |
| Intracellular non-membrane-bounded organelle | 212 | 5.33E−06 | |
| Non-membrane-bounded organelle | 212 | 5.33E−06 | |
| Chromatin remodeling complex | 18 | 3.26E−05 | |
| Nucleolus | 72 | 1.81E−04 | |
| MF | Transcription regulator activity | 163 | 1.16E−09 |
| Transcription repressor activity | 50 | 1.35E−06 | |
| Transcription factor binding | 67 | 4.45E−06 | |
| Transcription activator activity | 56 | 1.36E−05 | |
| Transcription factor activity | 100 | 1.41E−04 | |
| Protein kinase activity | 68 | 5.01E−04 | |
| Transcription cofactor activity | 46 | 1.07E−03 | |
| Protein serine/threonine kinase activity | 50 | 3.67E−03 | |
| DNA binding | 190 | 5.00E−03 | |
| Phosphoprotein phosphatase activity | 25 | 8.40E−03 |
GO gene ontology; BP biological process; CC cellular component; MF molecular function; adj.p value: adjusted p value