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. 2018 May 21;37:107. doi: 10.1186/s13046-018-0772-9

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The effect of the PARP inhibitor, olaparib, and doxorubicin on the proliferation of osteosarcoma cells. Treatment with the PARP inhibitor, olaparib (a), and doxorubicin (b) significantly inhibited the growth of U2OS, SaOS2, MG63, and KHOS/NP osteosarcoma cells in a dose- and time-dependent manner. At the end of treatment, the cell viability was measured by an MTT assay. *, versus control, P < 0.05; **, versus control, P < 0.001