Table 4.
Multivariate Cox proportional hazard regression analysis for overall survival and relapse-free survival in overall osteosarcoma patients
| Characteristics | OS | P | RFS | P |
|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | |||
| Multivariate analysis Model 1a | ||||
| Tumor size, cm, > 8 (vs. ≤ 8) | 3.528 (0.937–13.284) | 0.062 | ||
| Age, yr., ≥ 30 (vs. < 30) | 2.404 (0.918–6.301) | 0.074 | ||
| Stage, I | 1 | 0.046 | 1 | 0.026 |
| II | 2.958 (0.333–26.295) | 0.331 | 5.204 (0.641–42.213) | 0.123 |
| III-IV | 1.631 (1.348–205.244) | 0.028 | 21.071 (1.989–223.276) | 0.011 |
| γH2AX, positive (vs. negative) | 12.239 (2.118–70.722) | 0.005 | 5.212 (1.372–19.800) | 0.015 |
| Multivariate analysis Model 2b | ||||
| Tumor size, cm, > 8 (vs. ≤ 8) | 3.158 (0.961–10.383) | 0.058 | ||
| Age, yr., ≥ 30 (vs. < 30) | 2.565 (0.993–6.625) | 0.520 | ||
| CSddrm, score 3–4 (vs. score 0–2) | 11.791 (2.427–57.294) | 0.002 | 11.312 (2.513–50.913) | 0.002 |
OS overall survival, RFS relapse-free survival, HR hazard ratio, 95% CI 95% confidence interval, CSddrm the combined score for the immunohistochemical expression of PARP1, γH2AX, BRCA1, and BRCA2
aVariables considered in multivariate analysis Model 1 were age, tumor size, tumor stage, distant metastasis, histologic grade, and the expression of PARP1, γH2AX, BRCA1, and BRCA2
bVariables considered in multivariate analysis Model 2 were age, tumor size, tumor stage, distant metastasis, histologic grade, and CSddrm