Table 5.
Multivariate Cox proportional hazard regression analysis for overall survival and relapse-free survival in stage I and II osteosarcoma patients
| Characteristics | OS | P | RFS | P |
|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | |||
| Multivariate analysis Model 1a | ||||
| Tumor size, cm, > 8 (vs. ≤ 8) | 4.617 (1.251–17.038) | 0.022 | 3.188 (0.982–10.349) | 0.054 |
| BRCA1, positive (vs. negative) | 4.257 (1.024–17.696) | 0.046 | ||
| γH2AX, positive (vs. negative) | 19.634 (2.412–159.853) | 0.005 | 6.366 (1.203–33.695) | 0.029 |
| Multivariate analysis Model 2b | ||||
| CSddrm, score 3–4 (vs. score 0–2) | 30.043 (3.724–242.374) | 0.001 | 27.986 (3.501–223.717) | 0.002 |
OS overall survival, RFS relapse-free survival, HR hazard ratio, 95% CI 95% confidence interval, CSddrm the combined score for the immunohistochemical expression of PARP1, γH2AX, BRCA1, and BRCA2
aVariables considered in multivariate analysis Model 1 were tumor size, tumor stage, histologic grade, and the expression of PARP1, γH2AX, BRCA1, and BRCA2
bVariables considered in multivariate analysis Model 2 were tumor size, tumor stage, histologic grade, and CSddrm