Figure 6.

Role of NADH oxidase in S. suis 2 virulence in the pig infection model. A, Survival curves of pigs infected with S. suis strains. Animals inoculated with PBS are not shown for simplicity. P = 0.0144 for comparison of the Δnox group with the WT group, and P = 0.0486 for comparison of the Δnox group with the CΔnox group (the log-rank test). B, Pathological examination of brain tissues of the infected pigs. C, Pathological examination of heart tissues of the infected pigs. D, Pathological examination of lungs tissues of the infected pigs. Arrowheads show the pathological changes. Representative images are shown for each group. Bars, 100 μm.