Table 3.
In vitro interactions of administered antibacterials by time-kill methods against blood Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae isolates of 19 critically-ill patients.
| Patient no | MEM+TIG † | MEM+GEN† | TIG+GEN† | MEM+TIG+GEN† | MEM+TIG+GEN†† | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | I | −0,17 | I | 0,64* | I | 0,13 | I | 0,91 | I | 0,27 |
| 2 | I | 0,38 | I | 0,14* | I | 1,3* | I | 1,5 | I | 0,20 |
| 3 | I | 0,26 | I | 0,31 | I | 0,07 | I | 1,02 | I | 0,71 |
| 4 | I | 0,42 | I | 0,41 | I | 0,23 | I | 1,03 | I | 0,62 |
| 5 | I | 0,41 | I | 0,78 | I | 0,36 | I | 1,39 | I | 1,11 |
| 6 | I | −0,10 | I | 0,54 | I | 0,10 | I | 0,63 | I | 0,09* |
| 7 | I | 0,39 | I | 0,42 | I | 0,35 | I | 0,84 | I | 0,42 |
| 8 | I | 1,07 | I | 0,32 | I | 0,25 | I | 0,54 | I | 0,22 |
| 9 | I | 0,59 | I | 0,43 | I | 0,64 | I | 1,13 | I | 0,49 |
| 10 | I | 0,59 | I | 0,63 | I | 0,43 | I | 1,25 | I | 0,62 |
| 11 | I | −0,24* | I | 0,30 | I | 0,07* | I | 0,36 | I | 0,06* |
| 12 | I | 1,80 | I | 0,70 | I | 0,48 | I | 1,02 | I | 0,32 |
| 13 |
I |
0,91 |
I |
0,43 |
I |
0,3 |
I |
0,73 |
I |
0,3 |
|
Patient no |
MEM+TIG† |
MEM+COL† |
TIG+COL† |
MEM+TIG+COL† |
MEM+TIG+COL†† |
|||||
| 14 | I | 0,9 | I | 0,44 | I | 1,33 | I | 1,84 | I | −0,49* |
| 15 | I | 0,16 | I | 0,45 | I | 0,50 | I | 1,31 | I | 0,81 |
| 16 | I | −0,24 | I | 0,25 | I | 0,35 | I | 1,11 | I | 0,76 |
| 17 | I | 0,27 | I | 1,23 | I | 1,07 | I | 1,45 | I | 0,22 |
| 18 | I | 0,15 | I | 0,18 | I | 0,30 | I | 0,42 | I | 0,24 |
| 19 | I | 0,14 | I | 0,07* | I | 0,26 | I | 0,94 | I | 0,68 |
Notes. Values are reported as mean Δlog; I, indifferent interaction.
*
Non statistically significant Δlog (p ≥ 0.05).
†
Δlog was calculated comparing the 2-drug or the 3-drug combination with the most effective single agent.
††
Δlog was calculated comparing the triple combination with the most effective double-antibiotic concentration.