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. Author manuscript; available in PMC: 2018 May 22.
Published in final edited form as: J Comp Neurol. 2017 May 11;525(11):2592–2610. doi: 10.1002/cne.24226

FIGURE 4.

FIGURE 4

No significant correlation between the number of mossy cells and seizure frequency in epileptic pilocarpine-treated mice. GluR2-immunostaining of the dentate gyrus from a control (a1) and epileptic mouse (a2). Sections are 50% of the distance from the septal pole to the temporal pole of the hippocampus. g = granule cell layer; h = hilus; m = molecular layer. (b) High correlation between the number of hilar GluR2-positive cell body profiles counted and the number of hilar GluR2-positive neurons per dentate gyrus estimated by the optical fractionator method in a subset of mice from this study (R = 0.997, p <0.001, ANOVA). Only hilar GluR2-positive cells with a soma diameter >12 μm were counted. (c) Septotemporal distribution of hilar GluR2-positive cell bodies. Values represent mean ± SEM. (d) Fewer hilar GluR2-positive neurons in epileptic mice (n = 127) compared to controls (n = 9, p ≤ 0.001, Mann–Whitney rank sum test). (e) No significant correlation between the number of hilar GluR2-positive neurons per dentate gyrus and seizure frequency (R = 0.156, p = 0.079, ANOVA)