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. Author manuscript; available in PMC: 2018 May 22.
Published in final edited form as: J Comp Neurol. 2017 May 11;525(11):2592–2610. doi: 10.1002/cne.24226

FIGURE 8.

FIGURE 8

No significant correlation between the number of parvalbumin-positive interneurons in the dentate gyrus and seizure frequency in epileptic pilocarpine-treated mice. Parvalbumin-immunostaining of the dentate gyrus in a control (a1) and epileptic mouse (a2). The dentate gyrus is larger but contains fewer parvalbumin-positive neurons in the epileptic mouse. Sections are 45% of the distance from the septal pole to the temporal pole of the hippocampus. g = granule cell layer; h = hilus; m = molecular layer. (b) High correlation between the number of parvalbumin-positive cell body profiles counted and the number of parvalbumin-positive neurons per dentate gyrus estimated by the optical fractionator method in a subset of mice from this study (R = 0.985, p <0.001, ANOVA). (c) Septotemporal distribution of parvalbumin-positive cell body profiles per section. Values represent mean ± SEM. (d) Fewer parvalbumin-positive neurons per dentate gyrus in epileptic mice (n = 122) compared to controls (n = 8, p <0.001, t test). (e) No significant correlation between the number of parvalbumin-positive neurons per dentate gyrus and seizure frequency (R = 0.002, p = 0.979, ANOVA)