Table 4.
Effect modification of the Calcium/Vitamin D (CaD) Trial intervention on the association of serum 25(OH)D concentrations with lung cancer risk
| Calcium/vitamin D Trial3 | ||||
|---|---|---|---|---|
|
| ||||
| Serum 25(OH)D | No intervention | Intervention | P-interaction | |
| All lung cancer1 | ||||
| <50 nmol/L | N (cases/controls) | 139/152 | 24/24 | |
| OR (95% CI) | 1.00 (Referent) | 0.99 (0.52-1.90) | 0.07 | |
| ≥50 nmol/L | N (cases/controls) | 128/107 | 7/15 | |
| OR (95% CI) | 1.22 (0.84-1.77) | 0.42 (0.16-1.14) | ||
|
| ||||
| Non-small cell lung cancer2 | ||||
| <50 nmol/L | N (cases/controls) | 93/152 | 17/24 | |
| OR (95% CI) | 1.00 (Referent) | 1.14 (0.54-2.39) | 0.09 | |
| ≥50 nmol/L | N (cases/controls) | 77/107 | 4/15 | |
| OR (95% CI) | 1.13 (0.74-1.72) | 0.39 (0.12-1.29) | ||
|
| ||||
| Adenocarcinoma2 | ||||
| <50 nmol/L | N (cases/controls) | 82/152 | 15/24 | |
| OR (95% CI) | 1.00 (Referent) | 1.20 (0.55-2.60) | 0.06 | |
| ≥50 nmol/L | N (cases/controls) | 70/107 | 3/15 | |
| OR (95% CI) | 1.20 (0.77-1.86) | 0.35 (0.09-1.30) | ||
1
Odds ratios were estimated by conditional logistic regression models, adjusted for race/ethnicity, BMI, serum retinol concentrations, and season of blood draw.
2
Odds ratios were estimated by unconditional logistic regression, adjusted for the covariates and matching factors (age and CT/OS status).
3
The no intervention group included women who were randomly assigned to the placebo arm in the CaD trial and those who did not participate in the trial. The intervention group included women who were randomly assigned to the calcium and vitamin D arm in the CaD trial.