Skip to main content
. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Biochim Biophys Acta. 2018 Apr 19;1864(7):2438–2447. doi: 10.1016/j.bbadis.2018.04.010

Figure 1. Anti-IL-7Rα treatment improves salivary secretion and reduces leukocyte infiltration of submandibular glands (SMGs) in NOD mice.

Figure 1

(A) Real-time PCR analysis of IL-7 and IL-7Rα levels in the SMGs of NOD mice aged 4 and 13 weeks. The results are presented relative to that of β-actin. Data are the average of analyses of 4–7 mice each group. Error bars represent the SEM. (B) Anti-IL-7Rα antibody or control IgG was i.p.-administered to 10-week-old female NOD mice 3 times weekly for 3 weeks. The stimulated salivary flow rate normalized to body weight is shown. (C) H&E staining of SMG sections from mice described in B (scale bar = 100μm). Bar graph shows the mean leukocyte focus score. Data are representative or the average of 7 mice each group.