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. Author manuscript; available in PMC: 2019 May 2.
Published in final edited form as: Neuron. 2018 Apr 12;98(3):521–529.e3. doi: 10.1016/j.neuron.2018.03.034

Figure 3. Cryo-electron microscopy structure identifies the Exon 5 encoded motif at domain and subunit interfaces.

Figure 3

(A) Cryo-EM structure of the intact GluN1b-GluN2B NMDA receptor at ~4.6 Å. The GluN1b subunits are colored magenta and gold while the GluN2B subunits are colored cyan and blue. (B) Highlighted region from (A), illustrating cryo-EM density for residues of the Exon 5 motif at the ATD/LBD interface. (C) Overlay of models from the GluN1a-GluN2B and GluN1b-GluN2B intact NMDA receptors. Note the large shift in position of GluN1 Lys190 between the GluN1a and GluN1b isoforms.