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Effect of TOPK overexpression and TOPK siRNA on HDAC1 and HDAC2 phosphorylation, and Histone 3 and Histone 4 acetylation in BV2 cells. (A-D) The expression of p-HDAC1/HDAC1, p-HDAC2/HDAC2, ac-H3/H3, and ac-H4/H4 in BV2 cells was determined by western blotting after transfection with TOPK overexpressing and TOPK siRNA vector for 48 h. Data are expressed as the mean ± SEM. * p < 0.05 versus control, N = 6. Statistics: Tukey’s honest significance test.
