Table 3.
Significant group differences in DT-MRI measures in regions of interests
| Model (DT-MRI ∼ group) |
Predictor (beta and P-values) |
Post-hoc t-tests (t and P-values) |
||||
|---|---|---|---|---|---|---|
| DT-MRI | R2 (P-value) | Group 2 (AC) | Group 3 (FAD) | HC versus AC | HC versus FAD | AC versus FAD |
| FA left mFWM | 0.04 (0.224) | − | − | − | − | − |
| FA right mFWM | 0.007 (0.417) | − | − | − | − | − |
| FA left iFWM | 0.03 (0.224) | − | − | − | − | − |
| FA right iFWM | −0.005 (0.495) | − | − | − | − | − |
| FA left gCC | 0.06 (0.133) | − | − | − | − | − |
| FA right gCC | −0.01 (0.568) | − | − | − | − | − |
| FA left sCC | −0.03 (0.850) | − | − | − | − | − |
| FA right sCC | −0.01 (0.527) | − | − | − | − | − |
| FA left CGH | 0.10 (0.069) | − | − | − | − | − |
| FA right CGH | 0.03 (0.224) | − | − | − | − | − |
| FA left CS | −0.003 (0.481) | − | − | − | − | − |
| FA right CS | 0.06 (0.146) | − | − | − | − | − |
| 〈D〉 left mFWM | 0.07 (0.133) | − | − | − | − | − |
| 〈D〉 right mFWM | 0.08 (0.096) | − | − | − | − | − |
| 〈D〉 left iFWM | 0.15 (0.024) | 0.04 (0.861) | 0.76 (0.003) | −0.2 (0.983) | −3.1 (0.008) | −2.9 (0.016) |
| 〈D〉 right iFWM | 0.03 (0.234) | − | − | − | − | − |
| 〈D〉 left gCC | 0.14 (0.024) | 0.07 (0.781) | 0.8 (0.003) | −0.3 (0.958) | −3.1 (0.008) | −2.8 (0.020) |
| 〈D〉 right gCC | 0.13 (0.036) | −0.01 (0.969) | 0.70 (0.007) | 0.04 (0.999) | −2.8 (0.018) | −2.8 (0.020) |
| 〈D〉 left sCC | 0.15 (0.024) | −0.2 (0.409) | 0.63 (0.012) | 0.8 (0.685) | −2.6 (0.032) | −3.3 (0.004) |
| 〈D〉 right sCC | 0.005 (0.417) | − | − | − | − | − |
| 〈D〉 left CGH | 0.16 (0.024) | 0.3 (0.287) | 0.85 (0.001) | −1.1 (0.533) | −3.5 (0.003) | −2.4 (0.054) |
| 〈D〉 right CGH | 0.24 (0.005) | −0.1 (0.693) | 0.86 (<0.001) | 0.4 (0.917) | −3.7 (0.001) | −4.0 (<0.001) |
| 〈D〉 left CS | 0.11 (0.055) | − | − | − | − | − |
| 〈D〉 right CS | 0.005 (0.417) | − | − | − | − | − |
〈D〉 = mean diffusivity; AC = asymptomatic carriers; CGH = hippocampal part of cingulum bundle; CS = centrum semiovale; FA = fractional anisotropy; FAD = familial Alzheimer’s disease; gCC = genu of corpus callosum; HC = healthy controls; iFWM = inferior frontal white matter; mFWM = middle frontal white matter; sCC = splenium of corpus callosum. Significant (P < 0.05) tests highlighted in bold. P-values for R2 are FDR-corrected.