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Effect of genotypes on the UPDRS motor score improvement following administration of l-DOPA
|
Genotypes at SLC6A3 | |||||
|---|---|---|---|---|---|
| rs3836790 (the VNTR in intron 8) | 5/5 (n = 3) | 5/6 (n = 25) | 6/6 (n = 33) | - | P-value |
| Response to l-DOPA | 14.0 ± 1.0 | 12.2 ± 2.6 | 17.2 ± 4.0 | <0.0001 | |
| rs28363170 (VNTR in 3'UTR) | 10/10 (n = 32) | 9/10 (n = 21) | 5/9 (n = 1) | 9/9 (n = 5) | |
| Response to l-DOPA | 16.8 ± 3.9 | 12.4 ± 3.4 | 14 | 13.8 ± 3.5 | 0.0003 |
Mean (SD) difference in the motor UPDRS score when comparing OFF and ON conditions.
