Table 2.
MicroRNAs implicated in microglia function
| MicroRNA | Reference | Reported involvement/function |
|---|---|---|
| Inflammation-related | ||
| Mir-9 | Akerblom et al., 2013; Kong et al., 2014; Yao et al., 2014 | Ischaemia, MCPIP1 and NF-κB signalling |
| Mir-17 | Jadhav et al., 2014b | NADPH oxidases and reactive oxygen species production |
| Mir-21 | Kong et al., 2014 | Ischaemia |
| Mir-22 | Parisi et al., 2013 | Purinergic signalling |
| Mir-29b | Fenn et al., 2013; Thounaojam et al., 2014 | Aging, TNFAIP3 and NF-κB signalling |
| Mir-32 | Mishra et al., 2012 | TRAF3 signalling |
| Mir-34a | Alexandrov et al., 2013; Zhao et al., 2013; Su et al., 2014 | NF-κB signalling and TREM2-regulated phagocytosis activity, p53 signalling |
| Mir-124a | Ponomarev et al., 2011; Willemen et al., 2012; Freilich et al., 2013; Kong et al., 2014 | CEBPA–SPI1 (PU.1) signalling, cell activation, cell quiescence |
| Mir-125b | Parisi et al., 2013 | Purinergic signalling, STAT3 signalling |
| Mir-132 | Kong et al., 2014 | Ischaemia |
| Mir-134 | Kong et al., 2014 | Ischaemia |
| Mir-138 | Kong et al., 2014 | Ischaemia |
| Mir-142 | Chaudhuri et al., 2013 | Viral infections, SIRT1 regulation |
| Mir-145 | Freilich et al., 2013; Su et al., 2014 | Contribute to alternative activation, IL4/STAT6 signalling, p53 signalling |
| Mir-146a | Faraco et al., 2009; Rom et al., 2010; Li et al., 2011; Saba et al., 2012; Pareek et al., 2014 | Promoting and resolving inflammation, tumour suppression, NF-κB and JAK-STAT signalling |
| Mir-146b | Parisi et al., 2013 | Purinergic signalling |
| Mir-155 | Tarassishin et al., 2011; Cardoso et al., 2012; Freilich et al., 2013; Lippai et al., 2013; Moore et al., 2013; Parisi et al., 2013; Pareek et al., 2014 | Contribute to classical activation state, SOCS1 activity |
| Mir-181a | Dave and Khalili, 2010; Kong et al., 2014 | Ischaemia |
| Mir-195 | Shi et al., 2013 | Autophagy |
| Mir-200b | Jadhav et al., 2014a | cJun/MAPK signalling |
| Mir-221 | Kong et al., 2014 | Ischaemia |
| Mir-222 | Kong et al., 2014 | Ischaemia |
| Mir-365 | Parisi et al., 2013 | NFKB signalling, IL6/STAT3 signalling |
| Mir-424 | Zhao et al., 2013 | Cell cycle regulation and pro-inflammatory pathways |
| Mir-689 | Freilich et al., 2013 | Canonical pro-inflammatory pathway |
| Mir-711 | Freilich et al., 2013 | Canonical pro-inflammatory pathway |
| Growth factor-related | ||
| Let7f | Selvamani et al., 2012 | Ischaemia and IGF1 signalling |
| Mir-29b | Fenn et al., 2013 | IGF1 and CX3CL1 signalling |
| Apoptosis-related | ||
| Mir-21 | Zhang et al., 2012b | Hypoxia and FasL signalling |