Table 3.
Mean values of all variables by FokI genotype in both groups.
| VDR rs2228570 C > T (FokI) |
||||||||
|---|---|---|---|---|---|---|---|---|
| Control group |
p-Value |
T2D |
p-Value |
|||||
| FF n = 53 |
Ff n = 75 |
ff n = 32 |
FF n = 24 |
Ff n = 96 |
ff n = 40 |
|||
| BMI (kg/m2) | 27.2 (25.7–28.7) |
27.8 (27.0–28.6) |
29.1 (27.0–31.3) |
0.509 | 31.3 (28.3–34.4) |
30.6 (29.4–31.8) |
31.7 (29.7–33.6) |
0.434 |
| WC (cm) | 90.6 (87.5–93.7) |
93.2 (91.2–95.2) |
93.0 (88.0–97.4) |
0.394 | 100.0 (92.5–107.2) |
98.0 (95.3–100.3) |
97.4 (93.3–101.5) |
0.781 |
| Total cholesterol (mg/dl) | 193.4 (183.0–203.8) |
195.2 (185.4–205.0) |
191.6 (179.1–204.0) |
0.710 | 181.4 (162.0–201.0) |
197.1 (185.4–209.0) |
198.0 (178.0–217.9) |
0.437 |
| HDL cholesterol (mg/dl) | 38.2 (34.6–42.0) |
39.1 (36.3–42.0) |
37.5 (34.2–40.8) |
0.995 | 39.1 (29.5–48.7) |
33.0 (30.8–35.3) |
32.8 (28.1–37.5) |
0.317 |
| Triglycerides (mg/dl) | 140.0 (120.4–159.5) |
146.7 (129.3–164.0) |
133.8 (117.0–150.6) |
0.974 | 110.3 (83.2–137.3) |
153.4 (135.8–171.0) |
146.4⁎ (123.5–169.4) |
0.214 |
| Fasting glucose (mg/dl) | 86.7 (82.8–90.6) |
90.1 (86.9–93.3) |
90.0 (85.7–94.4) |
0.426 | 140.1 (121.5–158.7) |
133.3 (123.1–143.5) |
168.3 (119.0–217.5) |
0.495 |
| Fasting insulin (uUI/ml) | 5.1 (3.6–6.6) |
5.2 (4.2–6.2) |
5.6 (4.0–7.2) |
0.222 | 11.3 (6.9–16.1) |
14.3 (8.0–20.5) |
12.8 (9.1–16.5) |
0.173 |
| HOMA-IR | 1.3 (0.9–1.7) |
1.2 (0.9–1.5) |
1.3 (0.9–1.7) |
0.173 | 3.05 (1.4–4.7) |
2.93 (2.2–3.6) |
4.55⁎⁎ (3.0–6.0) |
0.021 |
| US-CRP (mg/dl) | 2.4 (1.5–3.3) |
2.8 (2.2–3.4) |
2.6 (1.5–3.8) |
0.461 | 2.7 (1.7–3.6) |
3.9 (3.0–4.8) |
3.8 (2.4–5.0) |
0.805 |
| 25(OH)D3 (nmol/l) | 59.4 (52.3–66.5) |
61.9 (53.7–70.1) |
57.3 (48.0–66.6) |
0.697 | 57.0 (48.9–65.1) |
56.0 (49.1–62.4) |
50.0 (42.7–57.3) |
0.210 |
Data are mean (95%CI). p value = Kruskal–Wallis test.
⁎⁎
Multiple comparisons between groups, Ff v/s ff, p = 0.0031.
⁎
Significant for the genotype FF v/s ff.