Table 1.

Significantly Enriched Functional Pathways Altered by Down-Regulated miRNAs

KEGG pathway	FDR
Fatty acid biosynthesis	5.63 × 10−12
Cell cycle	6.08 × 10−10
Viral carcinogenesis	1.04 × 10−9
Bladder cancer	1.97 × 10−7
Proteoglycans in cancer	6.24 × 10−6
Hepatitis B	6.24 × 10−6
Central carbon metabolism in cancer	1.46 × 10−5
Neurotrophin-signaling pathway	1.46 × 10−5
Chronic myeloid leukemia	1.46 × 10−5
Non-small cell lung cancer	1.90 × 10−5
ErbB-signaling pathway	2.86 × 10−5
Glioma	2.86 × 10−5
Epstein-Barr virus infection	6.38 × 10−5

miRNAs with >fourfold less expression in A549^shRNA.Sdc1 cells compared with A549^shRNA.scr cells were uploaded into miRPath software version 3,³² and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis was performed using validated targets identified in DIANA-TarBase software version 7.0.³³ Only pathways with a false discovery rate (FDR) of <0.0001 were listed.

ErbB, epidermal growth factor receptor.