Table 2.

Significantly Enriched Functional Pathways Altered by Up-Regulated miRNAs

KEGG pathway	FDR
ECM–receptor interaction	1.79 × 10−15
Prion diseases	8.47 × 10−11
Protein processing in endoplasmic reticulum	1.06 × 10−10
Fatty acid biosynthesis	2.05 × 10−7
Spliceosome	2.05 × 10−7
Viral carcinogenesis	4.03 × 10−6
Hippo signaling pathway	4.43 × 10−6
Proteoglycans in cancer	7.59 × 10−6
Central carbon metabolism in cancer	4.02 × 10−5

miRNAs with more than fourfold more expression in A549^shRNA.Sdc1 cells compared with A549^shRNA.scr cells were uploaded into miRPath software version 3,³² and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis was performed using validated targets identified in DIANA-TarBase software version 7.0.³³ Only pathways with a false discovery rate (FDR) of <0.0001 were listed.

ECM, extracellular matrix.