Table 4.
Functional Pathways Identified Both in the Analysis of the Predicted Targets of miRNAs in Exosomes that Were More in Syndecan-1–Deficient Conditions and in the Analysis of Genes Down-Regulated in Adenocarcinoma Samples
| KEGG pathway | FDR |
|---|---|
| Focal adhesion | 1.58 × 10−16 |
| Endocytosis | 1.12 × 10−11 |
| Regulation of actin cytoskeleton | 7.85 × 10−10 |
| Small cell lung cancer | 4.70 × 10−9 |
| Gap junction | 2.09 × 10−5 |
| Ubiquitin mediated proteolysis | 2.70 × 10−5 |
| Neurotrophin signaling pathway | 7.18 × 10−5 |
| Prion diseases | 2 × 10−4 |
| Adherens junction | 2 × 10−4 |
| Chronic myeloid leukemia | 2 × 10−4 |
| Prostate cancer | 3 × 10−4 |
| ECM–receptor interaction | 7 × 10−4 |
| Glioma | 5.3 × 10−3 |
| Protein export | 5.4 × 10−3 |
| Dorsoventral axis formation | 6.6 × 10−3 |
| Spliceosome | 1.2 × 10−2 |
| Protein processing in endoplasmic reticulum | 1.5 × 10−2 |
| Cell cycle | 3.9 × 10−2 |
ECM, extracellular matrix; FDR, false discovery rate; KEGG, Kyoto Encyclopedia of Genes and Genomes.