Figure 1.

Pan–histone deacetylase (HDAC) inhibitor, panobinostat, decreased hepatic and renal cystogenesis in polycystic kidney (PCK) rats. Drug-treated rats received daily injection of panobinostat (30 mg/kg), and the untreated group were injected with equal doses of dimethyl sulfoxide for 6 weeks. A and B: Representative images of Picrosirius Red–stained liver (A) and kidney (B) sections of untreated and panobinostat-treated PCK rats. Scatter plots depict cystic and fibrotic areas of individual liver lobes and kidneys analyzed. Data are expressed as means ± SD. n = 3 female and 3 male drug-treated rats; n = 4 female and 4 male untreated rats. ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001. Scale bars = 250 μm (B). Original magnification, ×4 (A).