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. 2018 Apr;188(4):981–994. doi: 10.1016/j.ajpath.2017.12.016

Figure 3.

Figure 3

Selective histone deacetylase 6 (HDAC6) inhibitor, ACY-738, decreases hepatic and renal cystogenesis in PCK rats. ACY-738 was given to polycystic kidney (PCK) rats in a chow diet, and the control group received standard chow for 6 weeks. A and B: Representative images of Picrosirius Red–stained liver (A) and kidney (B) sections of untreated rats and rodents treated with ACY-738. Scatter plots depict cystic and fibrotic areas of individual liver lobes and kidneys analyzed. Data are expressed as means ± SD. n = 3 female and 4 male ACY-738–treated PCK rats; n = 4 female and 4 male rats in the control group. ∗P < 0 0.05, ∗∗∗P < 0.001. Scale bars = 250 μm (B). Original magnification, ×4 (A).