Table 2.
Gross Anatomy and Cystic and Fibrotic Areas in Polycystic Kidney Rats Treated with ACY-1215 and ACY-241
| Variables | Untreated | ACY-1215 | ACY-241 |
|---|---|---|---|
| Body weight, g | |||
| Male | 471.6 ± 52.6 | 395.8 ± 62.9 | 409.2 ± 40.4 |
| Female | 274.0 ± 12.4 | 272.0 ± 11.6 | 278.7 ± 10.6 |
| Liver weight, g | |||
| Male | 22.4 ± 4.2 | 19.6 ± 1.9 | 20.6 ± 3.4 |
| Female | 14.3 ± 0.9 | 13.9 ± 1.3 | 14.0 ± 0.9 |
| Liver/body weight, % | |||
| Male | 4.9 ± 0.2 | 4.6 ± 0.2∗∗ | 4.6 ± 0.2∗ |
| Female | 5.3 ± 0.3 | 4.9 ± 0.3∗ | 4.9 ± 0.2∗ |
| Kidney weight, g | |||
| Male | 6.3 ± 1.4 | 4.9 ± 0.5 | 5.1 ± 0.7 |
| Female | 4.2 ± 0.6 | 3.9 ± 0.9 | 3.6 ± 0.6 |
| Kidney/body weight, % | |||
| Male | 1.7 ± 0.3 | 1.5 ± 0.2∗ | 1.6 ± 0.2∗ |
| Female | 1.4 ± 0.2 | 1.3 ± 0.1∗ | 1.3 ± 0.1∗ |
| Hepatic cystic area, % of total parenchyma | 15.6 ± 4.0 | 10.0 ± 2.0∗∗∗∗ | 11.1 ± 2.5∗∗∗ |
| Hepatic fibrotic area, % of total parenchyma | 8.6 ± 1.4 | 5.5 ± 1.7∗∗∗∗ | 6.5 ± 1.3∗∗∗∗ |
| Renal cystic area, % of total parenchyma | 28.4 ± 7.2 | 20.5 ± 6.0∗∗∗ | 23.7 ± 4.8∗∗ |
| Renal fibrotic area, % of total parenchyma | 3.2 ± 0.4 | 2.2 ± 0.5∗∗∗ | 2.5 ± 0.4∗∗∗ |
Data are expressed as means ± SD.
∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, and ∗∗∗∗P < 0.0001 untreated versus ACY-1215 or ACY-241.