Table 5.
Serum Biochemistry in Polycystic Kidney Rats Treated with ACY-1215, Pasireotide, and ACY-1215 + Pasireotide Combination
| Variable | Untreated | ACY-1215 | Pasireotide | ACY-1215 + PAS |
|---|---|---|---|---|
| γ-GT, U/L | 5.00 ± 0.00 | 5.00 ± 0.00 | 5.00 ± 0.00 | 5.00 ± 0.00 |
| ALT (GPT), U/L | 60.50 ± 7.22 | 54.25 ± 4.79 | 75.80 ± 20.56 | 47.20 ± 5.89∗ |
| ALP, U/L | 447.52 ± 87.16 | 509.52 ± 148.20 | 451.60 ± 95.69 | 361.75 ± 44.85 |
| Total bilirubin, mg/dL | 0.35 ± 0.06 | 0.35 ± 0.06 | 0.32 ± 0.04 | 0.30 ± 0.00 |
| Albumin, g/dL | 3.98 ± 0.59 | 4.15 ± 0.34 | 4.38 ± 0.41 | 3.60 ± 0.70 |
| Urea nitrogen, mg/dL | 15.75 ± 2.06 | 14.50 ± 1.00 | 14.00 ± 1.22 | 14.61 ± 3.29 |
| Cholesterol, mg/dL | 174.75 ± 18.92 | 161.25 ± 14.31 | 163.60 ± 25.26 | 145.00 ± 19.96 |
Data are expressed as means ± SD.
ALP, alkaline phosphatase; ALT, alanine aminotransferase; GPT, alanine aminotransferase; GT, glutamyl transferase.
∗
P < 0.05 untreated versus ACY-1215 + pasireotide combination.