Table 3. The use of targeted drugs according to tumor risk profile and line of treatment.

Line of treatment	Risk profile	Standard	Alternative
First-line	Low/moderate	Bevacizumab + IFN-alpha Pazopanib Sunitinib	High-dose interleukin-2
	High	Temsirolimus	Pazopanib. sunitinib
Line of treatment	Prior treatment with:	Standard	Alternative
Second-line	Cytokines	Axitinib	Pazopanib Sorafenib
	VEGF failure	Everolimus
	Sunitinib	Axitinib Everolimus
	Temsirolimus	Axitinib Pazopanib Sorafenib Sunitinib

IFN-alpha. interferon-alpha; VEGF. vascular endothelial growth factor