Table 2.

Prospective analysis of the association between RTL and HCC cancer risk

RTL values	Number of total patients	Number of HCC patients (%)	Univariate		Multivariate*		Log-rank P
			HR (95% CI)	P value	HR (95% CI)	P value
In patients with a 1-year exclusion window (n = 323)
By median
≤Median	162	6 (3.7)	1.00		1.00
>Median	161	31 (19.3)	6.43 (2.68–15.43)	3.1 × 10–5	4.93 (2.00–12.13)	0.0005	1.7 × 10–6
By tertile
1st tertile	108	3 (2.8)	1.00		1.00
2nd tertile	108	11 (10.2)	3.31 (0.92–11.91)	0.067	3.49 (0.96–12.69)	0.058
3rd tertile	107	23 (21.5)	10.09 (3.03–33.69)	0.0002	8.30 (2.42–28.41)	0.0008	2.5 × 10–6
P for trend				8.3 × 10–6		0.0002
In patients with a 2-year exclusion window (n = 258)
By median
≤Median	129	3 (2.3)	1.00		1.00
>Median	129	26 (20.2)	9.77 (2.95–32.32)	0.0002	7.58 (2.24–25.72)	0.001	4.4 × 10–6
By tertile
1st tertile	86	2 (2.3)	1.00		1.00
2nd tertile	87	8 (9.2)	3.58 (0.76–16.97)	0.11	4.10 (0.86–19.69)	0.078
3rd tertile	85	19 (22.4)	12.23 (2.84–52.64)	0.0008	10.52 (2.37–46.65)	0.002	9.3 × 10–6
P for trend				3.7 × 10–5		0.0004
In patients with a 5-year exclusion window (n = 153)
By median
≤Median	77	2 (2.6)	1.00		1.00
>Median	76	13 (17.1)	7.23 (1.63–32.16)	0.009	7.51 (1.56–36.18)	0.012	0.002
By tertile
1st tertile	51	2 (3.9)	1.00		1.00
2nd tertile	52	2 (3.8)	0.84 (0.12–6.04)	0.86	1.02 (0.14–7.63)	0.98
3rd tertile	50	11 (22.0)	6.11 (1.35–27.65)	0.019	6.77 (1.37–33.38)	0.019	0.0009
P for trend				0.005		0.008

*Multivariate analysis adjusted for age, gender, smoking status, drinking status, family history of cancer and cirrhosis status.