Table 1.
Selected characteristics of study participants in the current analysis from the Breast Cancer Association Consortium (BCAC) and Shanghai Breast Cancer Genetics Study (SBCGS)
| Characteristics | BCAC_Asian | SBCGS-GWAS | SBCGS-exome chip |
|---|---|---|---|
| (N = 12 893) | (N = 4866) | (N = 6457) | |
| Total no. of cases/controls | 6269/6624 | 2731/2135 | 3063/3394 |
| Age (year, mean ± SD) | 51.3 ± 10.4 | 50.7 ± 9.1 | 53.5 ± 9.5 |
| Age at menarche (year, mean ± SD) | 13.9 ± 1.9 | 14.6 ± 1.7 | 14.6 ± 1.7 |
| Age at menopause (year, mean ± SD) | 49.0 ± 4.8 | 48.8 ± 4.7 | 49.0 ± 4.3 |
| Postmenopausal (%) | 47.5 | 41.7 | 52.0 |
| ER status (%) | |||
| Positive | 26.1 | 32.6 | 29.6 |
| Negative | 12.5 | 15.8 | 16.0 |
| Othera | 61.4 | 51.6 | 54.4 |
| Progesterone receptor status (%) | |||
| Positive | 22.4 | 30.6 | 26.5 |
| Negative | 13.1 | 17.7 | 19.0 |
| Othera | 64.6 | 51.7 | 54.5 |
| Human epidermal growth factor receptor 2 status (%) | |||
| Positive | 6.4 | 7.4 | 9.4 |
| Negative | 8.6 | 18.7 | 20.9 |
| Othera | 85.1 | 73.9 | 69.7 |
aOther includes ‘Unknown, not tested, neutral’.