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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Curr Opin Neurobiol. 2017 Nov 6;47:131–137. doi: 10.1016/j.conb.2017.10.003

Figure 2. Morphological phenotypes observed when RSCs are disrupted.

Figure 2

Normally, a fully mature RSC will completely ensheathe every axon with cytoplasm to insulate it from other axons (top left). However, when RSCs are disrupted in different mutants, one of the most commonly observed defects is incomplete ensheathment of axons such that some axons remain in direct contact with other axons (top middle). This is distinct from radial sorting deficits in immature SCs where large diameter axons (pink) remain within bundles (top right), although the two phenotypes are often observed together. Another phenotype often observed with failed RSC ensheathment, is an increase in the number of axons per Remak bundle (bottom left). In contrast, some mutants display smaller Remak bundles (bottom middle). Finally, a few mutants have described phenotypes in which RSCs wrap multiple layers of membrane around axons (bottom right). Interestingly, the mutants displaying RSC wrapping have also displayed smaller Remak bundles.