Table 1.
Boltzmann parameters for the activation and inactivation of tetrodotoxin-sensitive (TTX-S) and resistant (TTX-R) INa in control and Nf1 sgRNA-transfected dorsal root ganglion neurons.
| V0.5 (mV) | k | |
|---|---|---|
| TTX-S | ||
| INa activation | ||
| Control (n=9) | −27.2 ± 0.7 | 5.0 ± 0.3 |
| Nf1 gRNA (n=11) | −30.0 ± 0.3 | 4.3 ± 0.3 |
| Nf1 gRNA + t-CNRP1 (n=11) | −24.7 ± 2.1a | 7.0 ± 1.3 |
| INa inactivation | ||
| Control (n=9) | −64.0 ± 3.2 | 7.7 ± 1.5 |
| Nf1 gRNA (n=11) | −51.4 ± 7.0 | 17.2 ± 1.8b |
| Nf1 gRNA + t-CNRP1 (n=11) | −68.3 ± 1.3a | 13.5 ± 0.7 |
| TTX-R | ||
| INa activation | ||
| Control (n=9) | −20.0 ± 0.7 | 7.8 ± 0.7 |
| Nf1 gRNA (n=11) | −26.9 ± 0.7b | 5.8 ± 0.2 |
| Nf1 gRNA + t-CNRP1 (n=11) | −19.9 ± 1.4a | 5.8 ± 0.4 |
| INa inactivation | ||
| Control (n=9) | −30.0 ± 2.4 | 5.6 ± 1.6 |
| Nf1 gRNA (n=11) | −36.3 ± 5.1 | 8.2 ± 2.6 |
| Nf1 gRNA + t-CNRP1 (n=11) | −43.9 ± 7.1 | 15.7 ± 3.5 a |
a
p < 0.05 vs Nf1 sgRNA (One-way ANOVA with Bonferroni’s multiple comparison test);
b
p < 0.05 vs control (One-way ANOVA with Bonferroni’s multiple comparison test);