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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Biochim Biophys Acta. 2018 Apr 21;1864(7):2420–2429. doi: 10.1016/j.bbadis.2018.04.014

Fig. 1. A schematic representation of the visual cycle and the target of CU239.

Fig. 1

All-trans-ROL undergoes a cascade of enzymatic reactions in the retinal pigmented epithelium (RPE), producing a light sensitive chromophore 11-cis-RAL. 11-cis-RAL binds with opsin in photoreceptor outer segment that allows photon capture. All-trans-RAL, a photo-isomerized product of 11-cis-RAL, has disease implication when accumulated in excessive amounts. CU239 selectively inhibits RPE65 and ameliorates the retinal damage induced by accelerated accumulation of all-trans-RAL in LIRD model.