Table 5.

Respiratory response to submaximal exercise and albuterol.

	Exercise				Albuterol
	Baseline	Low	Moderate	Vigorous	Baseline	60-min Post	110-Min post
FVC (L)
Healthy	4.6 ± 0.8	3.8 ± 0.2	3.8 ± 1.1	4.1 ± 1.1	4.8 ± 0.9	4.7 ± 0.7	4.8 ± 0.7
CF	3.9 ± 1.3	3.6 ± 1.3	3.6 ± 1.3	3.2 ± 1.0	4.0 ± 1.3	4.2 ± 1.2	4.1 ± 1.3
FVC (% predicted)
Healthy	98 ± 17	82 ± 11	81 ± 25	86 ± 28	104 ± 18	100 ± 16	101 ± 16
CF	90 ± 26	82 ± 24	81 ± 24	67 ± 24	91 ± 26	95 ± 26	94 ± 26
FEV1 (L)
Healthy	3.9 ± 0.8	3.4 ± 0.2	3.5 ± 1.2	3.8 ± 1.2	3.9 ± 0.9	4.1 ± 0.9	4.1 ± 0.9
CF	3.0 ± 1.2*	2.9 ± 1.2*	3.0 ± 1.2*	2.7 ± 1.0	3.0 ± 1.2	3.2 ± 1.3	3.2 ± 1.3
FEV1 (% predicted)
Healthy	112 ± 19	102 ± 9	95 ±28	104 ± 27	113 ± 20	116 ± 20	117 ± 21
CF	86 ± 27*	80 ± 25*	82 ± 25*	71 ± 23*	83 ± 28*	90 ± 30	91 ± 30
FEF25–75 (L/sec)
Healthy	4.2 ± 0.9	3.7 ± 0.1	4.2 ± 2.1	4.2 ± 2.0	3.9 ± 1.3	4.6 ± 1.6	4.6 ± 1.5
CF	2.7 ± 1.5*	2.7 ± 1.4*	3.1 ± 1.5*	2.7 ± 1.4	2.4 ± 1.4*	2.9 ± 1.9	2.9 ± 1.6
FEF25–75 (%predicted)
Healthy	116 ± 21	105 ± 17	105 ± 47	108 ± 44	105 ± 33	123 ±41	125 ± 38
CF	70 ± 36*	66 ± 29*	74 ± 32*	64 ± 30	62 ± 33*	73 ± 43*	74 ± 38*
DLNO (mL/min/mmHg)
Healthy	92.1 ± 17.5	103.1 ± 22.9	111.8 ± 19.2	119.8 ± 28.8	80.9 ± 15.5	81.4 ± 13.4	82 ± 14
CF	62.7 ± 25.1*	70.3 ± 28.5*	83.1 ± 28.9*	90.7 ± 35.6	64.0 ± 25.6	68.8 ± 26.3	71 ± 25
VA (mL)
Healthy	2916 ± 429	3469 ± 648	2916 ± 429	3423 ± 821	2692 ± 706	2872 ± 569	2894 ± 662
CF	2372 ± 726	2344 ± 755*	2372 ± 726*	2390 ± 772*	2411 ± 596	2397 ± 696	2431 ± 746
DLNO/VA
Healthy	0.03 ± 0.0	0.07 ± 0.08	0.03 ± 0.01	0.04 ± 0.01	0.03 ± 0.01	0.03 ± 0.0	0.03 ± 0.0
CF	0.03 ± 0.01	0.03 ± 0.01*	0.03 ± 0.01	0.04 ± 0.01	0.03 ± 0.01	0.03 ± 0.01	0.03 ± 0.01

FVC = forced vital capacity; FEV₁ = forced expiratory volume after one second of FVC; FEF_25–75 = forced expiratory flow at 25–75% of FVC. DLNO = diffusion capacity of the lungs for nitric oxide; V_A = alveolar volume; DLNO/V_A = DLNO corrected for V_A. Data presented are mean ± SEM

^*p < 0.0025 vs. healthy.