Table 1.

Exploration of VCP substrate scope

entrya	R =	solventb	yield (%)c	dr [trans:cis)d	er (trans)e	er (cis)e
1f,g	2-ester	THF	44	78:22	47:53	ND
2	2a	THF	70	40:60	83:17	72:28
3	2b	hex/THF	84	79:21	90:10	75:25
4		THF	82	77:23	88:12	76:24
5f		MeOH	82	76:22	70:30	65:35
6	2c	THF	79	68:32	85:15	75:25
7	2d	hex/THF	32	68:32	86:14	75:25
8	2e	hex/THF	77	73:27	90:10	79:21
9	2f	hex/THF	83	80:20	90:10	76:24
10	2g	hex/THF	81	82:18	90:10	73:27
11	2h	hex/THF	94	82:18	90:10	73:27

^aReactions were performed on a 0.1 mmol scale and were quenched by exposure to air. Reported data is the average of 2 separate experiments, unless noted.

^bStandard conditions: 2:1 hexanes:THF.

^cIsolated yield of a mixture of trans and cis diastereomers.

^dDetermined by ¹H NMR.

^eDetermined by CSP-HPLC (254 nm, uncorrected).

^fSingle experiment.

^gdr is crude before purification to remove cis, yield is pure trans.