TABLE II. Proteins from our pipeline with a potential epigenetic function in modulating the host epigenome. The list is annotated for proteins identified from the in silico secretome, the experimental secretome data, or both.
| ToxoDB ID a | Protein description a |
|---|---|
| In silico secretome | |
| TGME49_207690 | PDCD5 |
| TGME49_213310 | hypothetical protein |
| TGME49_239440 | protein kinase (incomplete catalytic triad) |
| TGME49_241870 | tRNA ligase class I (E and Q), catalytic domain-containing protein |
| TGME49_243280 | Met-10+ like-protein |
| TGME49_245660 | hypothetical protein |
| TGME49_257010 | sporozoite developmental protein |
| TGME49_271625 | serine--tRNA ligase |
| TGME49_277030 | isoleucyl-tRNA synthetase, putative |
| TGME49_281675 | hypothetical protein |
| TGME49_284010 | 5’-3’ exonuclease, N-terminal resolvase family domain-containing protein |
| TGME49_295050 | tRNA ligase class II core domain (G, H, P, S and T) domain-containing protein |
| TGME49_299810 | cysteine-tRNA synthetase (CysRS) |
| TGME49_305920 | endonuclease III family 1 protein |
| TGME49_312370 | RNA pseudouridine synthase superfamily protein |
| TGME49_312520 | tRNA dimethylallyltransferase |
| TGME49_313120 | DNA-directed RNA polymerase, alpha subunit |
| Experimental secretome | |
| TGME49_202490 | AP2 domain transcription factor AP2VIIa-7 |
| TGME49_206510 | toxolysin TLN4 |
| TGME49_207080 | histone lysine acetyltransferase MYST-B |
| TGME49_210310 | hypothetical protein |
| TGME49_210360 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 family protein |
| TGME49_219600 | hypothetical protein |
| TGME49_223880 | zinc finger, C3HC4 type (RING finger) domain-containing protein |
| TGME49_224480 | cell-cycle-associated protein kinase CLK, putative |
| TGME49_226510 | Sec23/Sec24 trunk domain-containing protein |
| TGME49_228120 | hypothetical protein |
| TGME49_231170 | RecF/RecN/SMC N terminal domain-containing protein |
| TGME49_239420 | protein kinase |
| TGME49_240090 | rhoptry kinase family protein ROP34, putative |
| TGME49_246060 | polymerase (RNA) mitochondrial (DNA directed) POLRMT |
| TGME49_246760 | hypothetical protein |
| TGME49_252500 | polo kinase |
| TGME49_253750 | PLU-1 family protein |
| TGME49_253890 | peptidase M16 inactive domain-containing protein |
| TGME49_267030 | ribonuclease type III Dicer |
| TGME49_268900 | dense granular protein GRA10 |
| TGME49_269885 | rhoptry metalloprotease toxolysin TLN1 |
| TGME49_271290 | hypothetical protein |
| TGME49_271740 | hypothetical protein |
| TGME49_278440 | SWI2/SNF2 Brahma-like putative |
| TGME49_285895 | AP2 domain transcription factor AP2V-2 |
| TGME49_289330 | ubiquitin carboxyl-terminal hydrolase family 2 protein |
| TGME49_292055 | calcium dependent protein kinase CDPK8 |
| TGME49_292235 | hypothetical protein |
| TGME49_294840 | zinc finger (CCCH type) motif-containing protein |
| TGME49_305750 | nucleolar gtp-binding protein 2, putative |
| TGME49_306660 | RNA pseudouridine synthase superfamily protein |
| TGME49_312830 | hypothetical protein |
| TGME49_313330 | rhoptry kinase family protein ROP27 |
| Both in silico and experimental secretome | |
| TGME49_201130 | rhoptry kinase family protein ROP33 |
| TGME49_207610 | rhoptry kinase family protein ROP36 (incomplete catalytic triad) |
| TGME49_221330 | DNA gyrase/topoisomerase IV, A subunit domain-containing protein |
| TGME49_229630 | eIF2 kinase IF2K-A (incomplete catalytic triad) |
| TGME49_262730 | rhoptry protein ROP16 |
| TGME49_294560 | rhoptry kinase family protein ROP37 (incomplete catalytic triad) |
| TGME49_309110 | tRNA methyl transferase |
a: retrieved from ToxoDB (Version 8.0).