Skip to main content
. 2018 Jun;93(6):645–656. doi: 10.1124/mol.118.111872

Fig. 11.

Fig. 11.

(A) Displacement of [3H]-NMS binding by GSK1034702 in CHO membranes expressing M1, M2, M3, M4, or M5 mAChRs. Experiments were performed against a KD concentration of [3H]-NMS. Nonspecific binding was determined by the addition of 10 μM atropine. Data are expressed as the means ± S.E.M. of three independent experiments. (B) ERK1/2 phosphorylation elicited by GSK1034702 at the M1, M2, M3, M4, or M5 mAChR expressed in CHO cells. Data are expressed as a percentage of the maximum response stimulated by ACh and are the means ± S.E.M. of three experiments performed in duplicate.