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Maximum agonist effect and potency of ACh, xanomeline, GSK1034702, and TBPB at stimulating IP1 accumulation in CHO Flp-In human M1 cells
Data are expressed as the means ± S.E.M. of 3–10 independent experiments performed in duplicate.
| Compound | IP1 |
||
|---|---|---|---|
| Emax | pEC50 | n | |
| ACh | 100 | 7.1 ± 0.1 | 10 |
| Xanomeline | 98.0 ± 1.5 | 8.2 ± 0.1 | 3 |
| GSK1034702 | 90.1 ± 2.9 | 7.1 ± 0.1 | 3 |
| TBPB | 55.2 ± 3.1 | 7.6 ± 0.2 | 4 |
