eTable 5. Overall results for the comparison of intraoral appliances vs placebo on minimum oxygen saturation.

	Data	Trials	Effect	95% CI	p	95% PrI	τ2	I2 (%)
Meta-analysis	MD	6	3.33	[1.38; 5.28]	0.007	–1.62; 8.28	2.19	96.8
Factor	Data	Trials	Effect	95% CI	p		τ2	I2 (%)
Follow-up (months)	Coefficient	5	–0.37	[–0.61; –0.14]	0.015		0.26	45.6
	Constant		7.2	[4.69; 9.70]	0.003
% of maximum protrusion	Coefficient	NA
	Constant
Appliance type (1- or 2-piece)	Coefficient	5	2.19	[–13.13; 17.51]	0.68		3.22	92
	Constant		1.5	[–38.15; 57.79]	0.77
Baseline BMI (kg/m2)	Coefficient	6	–0.22	[–1.88; 1.43]	0.725		2.7	92
	Constant		9.82	[–38.15; 57.79]	0.6
Baseline AHI (events/hour)		NA
Baseline age (years)	Coefficient	6	–0.27	[–1.14; 0.60]	0.129		1.35	94.9
	Constant		16.42	[–25.56; 58.39]	0.2
Ratio of male patients	Coefficient	6	22.38	[–10.19; 54.96]	0.129		1.35	94.9
	Constant		–14.03	[–39.43; 11.37]	0.2
Total sample	Coefficient	6	–0.05	[–0.11; 0.00]	0.06		0.9	51.5
	Constant		6.48	[2.91; 10.05]	0.007
Study design (crossover or parallel)	Coefficient	6	1.82	[–3.34; 6.97]	0.383		2.21	97.4
	Constant		1.9	[–2.67; 6.47]	0.313
Data type 1	Coefficient	NA
	Constant
Data type 2	Coefficient	6	–1.87	[–14.97; 11.22]	0.712		2.69	97.4
	Constant		3.37	[1.04; 5.70]	0.016
Data type 1	Coefficient	NA
Data type 2	Coefficient
	Constant
	Data	Trials	Effect	95% CI	p
Reporting bias (Egger’s test)	Coefficient	NA

CI. confidence interval; PrI. predictive interval; MD. mean difference; NA. not applicable; BMI. body mass index; AHI. apnea hypopnea index; Data type 1. origin of data used in the analysis 1 (increment calculated from parallel or cross-over trials); Data type 2. origin of data used in the analysis 2 (increment calculated from final values of cross-over trials).