Table 1.
Tissue | Mean weight mg(mL) ± SEM | Tissue concentration μg/g(mL) ± SEM | Total dose (μg) ± SEM | |
---|---|---|---|---|
Anterior segment | Aqueous | 0.429 ± 0.066 | 16.80 ± 0.47 | 7.26 ± 0.202 |
Cornea | 0.122 ± 0.003 | 2.86 ± 0.05 | 0.35 ± 0.006 | |
Conjunctiva | 0.119 ± 0.009 | 1.37 ± 0.41 | 0.076 ± 0.041 | |
Iris/ciliary body | 0.130 ± 0.012 | 2.81 ± 0.42 | 0.36 ± 0.055 | |
Anterior sclera | 0.285 ± 0.016 | 1.05 ± 0.091 | 0.30 ± 0.026 | |
Lens capsule | 0.013 ± 0.002 | 1.41 ± 0.41 | 0.019 ± 0.005 | |
Total…. | — | 8.37 ± 0.34 | ||
Posterior segment | Retina | 0.059 ± 0.001 | 1.83 ± 0.36 | 0.11 ± 0. 02 |
Vitreous | 1.90 ± 0.06 | 1.13 ± 0.37 | 2.13 ± 0.71 | |
Choroid/RPE | 0.080 ± 0.002 | 1.59 ± 0.05 | 0.15 ± 0.02 | |
Posterior sclera | 0.252 ± 0.011 | 0.64 ± 0.16 | 0.16 ± 0.04 | |
Total…. | — | 2.55 ± 0.79 | ||
Plasma | 379.0 | 0.00470 ± 0.00073 | 1.78 ± 0.28 | |
Total ketorolac | Anterior+posterior | + Plasma = | 12.70 ± 1.41 |
SEM, standard error of the mean.