Table 3. The levels of proinflammatory cytokines in supernatant in FLS among each groups (ng/L).
| Group | IL-1β | IL-6 | IL-8 | IL-17 |
|---|---|---|---|---|
| Control | 5.87 ± 0.33 | 6.82 ± 0.79 | 49.38 ± 13.57 | 16.28 ± 5.87 |
| MiR-146a mimic | 3.27 ± 0.23* | 3.65 ± 0.32* | 29.47 ± 5.76* | 6.23 ± 1.02* |
| MiR-146a inhibitor | 9.12 ± 0.56* | 8.94 ± 0.53* | 79.64 ± 14.52* | 31.67 ± 8.59* |
| Tak-242 | 3.23 ± 0.27* | 3.71 ± 0.34* | 29.51 ± 5.73* | 6.17 ± 1.07* |
| Mimic + LPS | 5.85 ± 0.41 | 6.78 ± 0.83 | 50.02 ± 12.85 | 15.77 ± 6.16 |
| TLR4 | 10.09 ± 0.11*# | 9.96 ± 0.21*# | 106.57 ± 7.13*# | 56.45 ± 4.01*# |
Note: *P < 0.05 compared with the control group; #P < 0.05 compared with the miR-146a inhibitor group; miR-146a: microRNA-146a; IL: interleukin. The experiment was repeated for three times. Each group had four wells from different patients every time, and cell samples form 12 patients were used in the experiments.