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. 2018 May 8;9(35):24041–24053. doi: 10.18632/oncotarget.25275

Figure 1. SLUG and TWIST are expressed in pilocytic astrocytomas and glioblastomas in human astrocytic tumors.

Figure 1

Immunohistochemical analyses showing SLUG (left column) and TWIST (right column) expression (SLUG and TWIST positive nuclei indicated with black arrows) in (A, F) normal appearing grey matter (NAGM), (B, G) pilocyctic astrocytoma WHO grade I showing vascular proliferations, (C, H) diffuse astrocytoma WHO grade II, (D, I) anaplastic astocytoma WHO grade III and (E, J) glioblastoma WHO grade IV showing vascular proliferations. (Scale bar = 100μm). Box-and-Whisker plots for (K) SLUG and (L) TWIST expression scores are depicted. P-values from all pair comparisons of different WHO grade astrocytomas were obtained using the non-parametric Wilcoxon test followed by Bonferroni post hoc test (p < 0.05 = *; p < 0.01 = **; p < 0.0001 = ***). Pilocytic astrocytoma, WHO grade I (PA; n=47); diffuse astrocytoma WHO grade II (DA; n=16); anaplastic astrocytoma WHO grade III (AA; n=35); glioblastoma WHO grade IV (GBM; n=252).