Table 5. Results for stratified analysis by selected variables.
| Head and neck + Esophagus | |||||||
|---|---|---|---|---|---|---|---|
| DII quartiles | |||||||
| 1 (−4.31 – −1.00) | 2 (–1.00 –0.11) | 3 (0.11–0.58) | 4 (0.58–2.02) | ||||
| Variables | Case/control (n) Multivariate ORa (95% CI) |
P for trend | interaction Pb | ||||
| Sex | Male | 134/538 | 192/607 | 225/628 | 275/693 | 0.012 | |
| 1.00 (Reference) 1.17 (0.88–1.55) | 1.21 (0.92–1.59) | 1.41 (1.08–1.85) | |||||
| Female | 40/233 | 51/163 | 53/142 | 58/77 | <0.001 | <0.001 | |
| 1.00 (Reference) 1.88 (1.13–3.13) | 1.91 (1.15–3.15) | 3.87 (2.22–6.75) | |||||
| Age | <60 | 61/264 | 89/312 | 113/383 | 188/395 | 0.001 | |
| 1.00 (Reference) 1.07 (0.71–1.61) | 1.16 (0.78–1.72) | 1.78 (1.22–2.60) | |||||
| ≥60 | 113/507 | 154/458 | 165/387 | 145/375 | 0.006 | 0.18 | |
| 1.00 (Reference) 1.52 (1.11–2.08) | 1.67 (1.22–2.28) | 1.54 (1.12–2.14) | |||||
| Smoking | Never | 45/378 | 48/279 | 45/254 | 63/224 | <0.001 | |
| 1.00 (Reference) 1.74 (0.98–3.08) | 1.91 (1.08–3.36) | 3.03 (1.65–5.55) | |||||
| Ever | 129/393 | 194/490 | 233/516 | 269/543 | 0.007 | 0.021 | |
| 1.00 (Reference) | 1.22 (0.90–1.66) | 1.37 (1.03–1.84) | 1.48 (1.10–1.98) | ||||
| Alcohol | Never | 37/26941/259 | 58/244 | 63/247 | <0.001 | ||
| consumption | 1.00 (Reference) | 1.14 (0.61–2.13) | 1.85 (1.02–3.34) | 3.21 (1.68–6.14) | |||
| Ever | 137/502 | 201/510 | 220/526 | 270/523 | 0.003 | 0.58 | |
| 1.00 (Reference) | 1.25 (0.93–1.68) | 1.17 (0.88–1.56) | 1.59 (1.20–2.12) | ||||
| Flushing | Yes | 79/383 | 97/383 | 124/377 | 143/412 | 0.040 | |
| phenotype | 1.00 (Reference) | 1.09 (0.69–1.72) | 1.56 (1.01–2.42) | 1.46 (0.93–2.30) | |||
| No | 88/363 | 137/368 | 140/378 | 179/346 | 0.005 | 0.67 | |
| 1.00 (Reference) | 1.49 (0.96–2.32) | 1.05 (0.67–1.64) | 2.05 (1.34–3.13) | ||||
| Teeth | 0–8 | 48/121 | 77/131 | 65/111 | 88/132 | 0.540 | |
| 1.00 (Reference) | 2.11 (0.88–5.05) | 1.40 (0.57–3.44) | 1.62 (0.62–4.25) | ||||
| 9–20 | 58/218 | 68/208 | 89/231 | 94/222 | 0.460 | 0.49 | |
| 1.00 (Reference) | 0.87 (0.45–1.68) | 1.00 (0.54–1.88) | 1.22 (0.65–2.29) | ||||
| ≥21 | 68/424 | 96/427 | 118/419 | 145/403 | 0.002 | ||
| 1.00 (Reference) | 1.20 (0.77–1.88) | 1.44 (0.94–2.20) | 1.86 (1.22–2.85) | ||||
| Occupation | Blue collar | 56/143 | 89/191 | 99/230 | 137/277 | 0.410 | |
| group | 1.00 (Reference) | 0.79 (0.39–1.59) | 0.80 (0.41–1.54) | 1.18 (0.61–2.26) | |||
| White collar | 38/198 | 40/241 | 62/234 | 77/244 | 0.080 | <0.001 | |
| 1.00 (Reference) | 0.91 (0.39–2.13) | 1.15 (0.54–2.48) | 1.78 (0.82–3.86) | ||||
| Other | 78/411 | 112/323 | 113/295 | 114/243 | 0.005 | ||
| 1.00 (Reference) | 1.70 (1.11–2.60) | 1.61 (1.06–2.46) | 1.97 (1.27–3.08) | ||||
aOdds ratios were estimated by conditional logistic models adjusted for smoking, ethanol consumption, flushing, phenotype, teeth and occupation group.
bInteractions were evaluated by likelihood ratio test between a model including a cross-product term between variables of interest and DII quartiles and a model without the term.