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Netarsudil blocks the profibrotic effects of TGF-β on HTM cells. Serum-starved primary HTM cells incubated for 24 h in the presence of either vehicle, 8 ng/mL human TGF-β2, 500 nM netarsudil, or 8 ng/mL TGF-β2 plus 500 nM netarsudil were fixed and stained for the fibrogenic markers α-SMA, fibroblast-specific protein 1 (FSP1), and Collagen 1A. α-SMA, α-smooth muscle actin; HTM, human trabecular meshwork; TGF-β2, transforming growth factor-β2.
